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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RUNX2
All Species:
16.06
Human Site:
S256
Identified Species:
32.12
UniProt:
Q13950
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q13950
NP_001015051.3
521
56648
S256
L
G
R
I
P
H
P
S
M
R
V
G
V
P
P
Chimpanzee
Pan troglodytes
XP_001142127
523
56886
S258
L
G
R
I
P
H
P
S
M
R
V
G
V
P
P
Rhesus Macaque
Macaca mulatta
XP_001100855
590
64548
S325
L
G
R
I
P
H
P
S
M
R
V
G
V
P
P
Dog
Lupus familis
XP_532158
467
50795
V205
I
P
H
P
S
M
R
V
G
V
P
P
Q
N
P
Cat
Felis silvestris
Mouse
Mus musculus
Q08775
607
66186
S342
L
G
R
I
P
H
P
S
M
R
V
G
V
P
P
Rat
Rattus norvegicus
Q63046
450
48538
P189
K
L
D
D
Q
T
K
P
G
S
L
S
F
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511294
367
39929
F106
D
D
S
K
P
S
L
F
S
E
R
L
S
D
L
Chicken
Gallus gallus
NP_989459
472
51671
L207
P
R
R
H
R
Q
K
L
D
D
S
K
P
S
L
Frog
Xenopus laevis
Q6PF39
462
50351
L201
F
S
E
R
L
S
E
L
E
H
F
R
R
T
A
Zebra Danio
Brachydanio rerio
NP_998023
467
51296
S205
P
P
K
P
P
L
F
S
E
R
L
S
E
L
E
Tiger Blowfish
Takifugu rubipres
NP_001027815
463
50317
D202
R
H
R
Q
K
L
E
D
P
P
K
A
G
L
F
Fruit Fly
Dros. melanogaster
Q9W349
826
84703
S438
K
A
L
H
E
L
E
S
L
R
R
S
A
K
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
88.3
72.1
N.A.
85
60.2
N.A.
66.9
88.2
59.8
76.5
72.7
23.2
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
88.3
75.8
N.A.
85.6
71
N.A.
67.7
89.6
71.2
82.3
80.2
33.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
100
0
N.A.
6.6
6.6
0
20
6.6
13.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
100
6.6
N.A.
6.6
6.6
0
33.3
6.6
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
0
0
0
0
0
0
9
9
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
9
9
9
0
0
0
9
9
9
0
0
0
9
0
% D
% Glu:
0
0
9
0
9
0
25
0
17
9
0
0
9
0
17
% E
% Phe:
9
0
0
0
0
0
9
9
0
0
9
0
9
0
9
% F
% Gly:
0
34
0
0
0
0
0
0
17
0
0
34
9
0
0
% G
% His:
0
9
9
17
0
34
0
0
0
9
0
0
0
0
0
% H
% Ile:
9
0
0
34
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
17
0
9
9
9
0
17
0
0
0
9
9
0
9
0
% K
% Leu:
34
9
9
0
9
25
9
17
9
0
17
9
0
17
17
% L
% Met:
0
0
0
0
0
9
0
0
34
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% N
% Pro:
17
17
0
17
50
0
34
9
9
9
9
9
9
34
42
% P
% Gln:
0
0
0
9
9
9
0
0
0
0
0
0
9
0
0
% Q
% Arg:
9
9
50
9
9
0
9
0
0
50
17
9
9
0
0
% R
% Ser:
0
9
9
0
9
17
0
50
9
9
9
25
9
17
0
% S
% Thr:
0
0
0
0
0
9
0
0
0
0
0
0
0
9
0
% T
% Val:
0
0
0
0
0
0
0
9
0
9
34
0
34
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _